Grant MC, Geoghegan L, Arbyn M, et al.Serial interval and incubation period of COVID-19: a systematic review and meta-analysis. Alene M, Yismaw L, Assemie MA, Ketema DB, Gietaneh W, Birhan TY.Updated content and resources to include new NIH Treatment Guidelines.New information about COVID-19-Associated Hypercoagulability.Refer to new guidance for Evaluation and Management Considerations for Neonates At Risk for COVID-19.Refer to new multisystem inflammatory syndrome in children (MIS-C) guidance for healthcare providers.Refer to updated symptoms of Coronavirus.Minor revisions for clarity and updates to footnotes throughout.Updated content to Clinical Presentation.Information on FDA approval of remdesivirĪs of June 20, 2020, to reflect the following:.Revisions for clarity and significant updates to footnotes throughout.New information for Pediatric Considerations.New information for Laboratory and Radiographic Findings.New information on reports of reinfection with variant viruses.New information on prolonged shedding of replication-competent SARS-CoV-2 in severely immunocompromised persons.New information on dermatologic manifestations associated with COVID-19.
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New information on potential for under-detection of occult hypoxemia by pulse oximetry, especially among persons with dark skin.Details on multisystem inflammatory syndrome.New section on moderately or severely immunosuppressed populations.New section about pregnancy and recent pregnancy.Updated information on the clinical presentation and course of COVID-19 among adults and children, including information about SARS-CoV-2 variants and reinfection.Patients who are reinfected with SARS-CoV-2 likely will experience less severe illness than during the initial infection, but some patients will experience more severe illness. When treating patients with COVID-19, the National Institutes of Health (NIH) external icon recommends that clinicians consider treating patients according to risk of progression to severe COVID-19 or the severity of COVID-19.Clinicians caring for special populations external icon including children, pregnant and recently pregnant people, people who are moderately or severely immunocompromised, people with confirmed or suspected multisystem inflammatory syndrome, and people with post-COVID conditions may have additional clinical considerations.A chest radiograph or computerized tomography (CT) images alone are not recommended to diagnose COVID-19. When testing for current SARS-CoV-2 infection, CDC recommends that clinicians use molecular or antigen tests (viral tests) that detect SARS-CoV-2 or its components, not a serologic test that detects antibodies.The clinical presentation of COVID-19 varies from asymptomatic infection to critical illness symptoms can vary over time.Clinical Progression, Management, and Treatment.